Durable response in a patient with recurrent respiratory papillomatosis treated with immune checkpoint blockade.

ABSTRACT:

Background

Immune checkpoint blockade can provide clinical benefit for patients with advanced cancer. Here, we report durable disease control over many years following PD-L1 blockade through induction of a viral antigen-specific T cell response in an adult patient with recurrent respiratory papillomatosis.

Methods

Antigen-specific T cell response assays, single cell RNA-sequencing, and RNA-scope was used to study clinical tissues.

Results

An HPV6 E2-specific T cell clone restricted to HLA-B*55, present at low frequency in the pre-treatment papilloma, significantly expanded after six doses of PD-L1 blockade and remained present and functional at the site of initial response in the larynx as a tissue resident memory T cell for 4 years. An associated reduction in E2 targ

SUBMITTER: Bai K 

PROVIDER: S-EPMC9452466 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature