Early detection of colorectal cancer based on circular DNA and common clinical detection indicators.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common cancer worldwide, and it is the second leading cause of death from cancer in the world, accounting for approximately 9% of all cancer deaths. Early detection of CRC is urgently needed in clinical practice.

Aim

To build a multi-parameter diagnostic model for early detection of CRC.

Methods

Total 59 colorectal polyps (CRP) groups, and 101 CRC patients (38 early-stage CRC and 63 advanced CRC) for model establishment. In addition, 30 CRP groups, and 62 CRC patients (30 early-stage CRC and 32 advanced CRC) were separately included to validate the model. 51 commonly used clinical detection indicators and the 4 extrachromosomal circular DNA markers NDUFB7, CAMK1D, PIK3CD and PSEN2 that we

SUBMITTER: Li J 

PROVIDER: S-EPMC9453338 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature