Effect of probiotics on hemodynamic changes and complications associated with cirrhosis: A pilot randomized controlled trial.

ABSTRACT:

Background

Bacterial translocation exacerbates the hyperdynamic circulation observed in cirrhosis and contributes to a more severe disease course. Probiotics may reduce bacterial translocation and may therefore be useful to redress the circulatory imbalance.

Aim

To investigate the effect of probiotics on hemodynamic parameters, systemic inflammation, and complications of cirrhosis in this randomized placebo-controlled trial.

Methods

This single-blind randomized placebo-controlled study included 40 patients with Child-Pugh class B and C cirrhosis; 24 patients received probiotics (Saccharomyces boulardii) for 3 mo, and 16 patients received a placebo over the same period. Liver function and the systemic hemodynamic status were evaluated pre- and post-intervention.

SUBMITTER: Maslennikov R 

PROVIDER: S-EPMC9453455 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature