Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments.
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ABSTRACT:
SUBMITTER: Gan L
PROVIDER: S-EPMC9453912 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments.
Gan Lei L Velásquez-Hernández Miriam de J MJ Emmerstorfer-Augustin Anita A Wied Peter P Wolinski Heimo H Zilio Simone Dal SD Solomon Marcello M Liang Weibin W Doonan Christian C Falcaro Paolo P
Chemical communications (Cambridge, England) 20220908 72
Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments <i>via</i> the dissolution of the shells and release of a protease inhibitor (antitrypsin). ...[more]
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