Multi-layered ZIF-coated cells for the release of bioactive molecules in hostile environments.

ABSTRACT: Metal-organic framework (MOF) coatings on cells enhance viability in cytotoxic environments. Here, we show how protective multi-layered MOF bio-composite shells on a model cell system (yeast) enhance the proliferation of living cells exposed to hostile protease-rich environments via the dissolution of the shells and release of a protease inhibitor (antitrypsin).

SUBMITTER: Gan L 

PROVIDER: S-EPMC9453912 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature