Prognostic value of FOXP3+ regulatory T cells in patients with diffuse large B-cell lymphoma: a systematic review and meta-analysis

ABSTRACT:

Objectives

We aimed to comprehensively evaluate the relationship between forkhead box P3 (FOXP3+) regulatory T cell (Treg) expression and diffuse large B-cell lymphoma (DLBCL) prognosis and to explore the sources of heterogeneity of the results.

Design

Systematic review and meta-analysis.

Data sources

We searched the Cochrane Library, PubMed, Embase and Web of Science databases up to 5 December 2021.

Eligibility criteria

We included studies that analysed the prognostic significance of FOXP3+ Tregs in DLBCL. We included studies reported in Chinese or English that reported HRs and related 95% CIs for prognosis.

Data extraction and synthesis

We extracted data from eligible studies. HRs and 95% CIs were used to assess the prognostic value.

Resul

SUBMITTER: Bai Y 

PROVIDER: S-EPMC9454056 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature