Striatal dopaminergic lesions contributed to the disease severity in progressive supranuclear palsy.

ABSTRACT:

Background

Reduced dopamine transporter (DAT) binding in the striatum has been reported in patients with progressive supranuclear palsy (PSP). However, the relationship between striatal dopaminergic lesions and the disease severity of PSP remains to be explored.

Objective

To investigate the contributions of striatal dopaminergic lesions to the disease severity of PSP.

Methods

One hundred patients with clinically diagnosed PSP were consecutively enrolled in this study. The disease severity was systemically assessed using the PSP rating scale (PSPrs), and the dopaminergic lesions were assessed using the ¹¹C-N-2-carbomethoxy-3-(4-fluorophenyl)-tropane positron emission tomography (¹¹C-CFT PET) imaging. To explore the correlations between striatal DA

SUBMITTER: Chen MJ 

PROVIDER: S-EPMC9454812 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature