Unknown

Dataset Information

0

NET Formation in Systemic Lupus Erythematosus: Changes during the COVID-19 Pandemic.


ABSTRACT: The severity of the coronavirus disease in 2019 (COVID-19) is strongly linked to a dysregulated immune response. This fuels the fear of severe disease in patients with autoimmune disorders continuously using immunosuppressive/immunomodulating medications. One complication of COVID-19 is thromboembolism caused by intravascular aggregates of neutrophil extracellular traps (NETs) occluding the affected vessels. Like COVID-19, systemic lupus erythematosus (SLE) is characterized by, amongst others, an increased risk of thromboembolism. An imbalance between NET formation and clearance is suggested to play a prominent role in exacerbating autoimmunity and disease severity. Serologic evidence of exposure to SARS-CoV-2 has a minor impact on the SLE course in a Swedish cohort reportedly. Herein, we assessed NET formation in patients from this cohort by neutrophil elastase (NE) activity and the presence of cell-free DNA, MPO-DNA, and NE-DNA complexes and correlated the findings to the clinical parameters. The presence of NE-DNA complexes and NE activity differed significantly in pre-pandemic versus pandemic serum samples. The latter correlated significantly with the hemoglobin concentration, blood cell counts, and complement protein 3 and 4 levels in the pre-pandemic but only with the leukocyte count and neutrophil levels in the pandemic serum samples. Taken together, our data suggest a change, especially in the NE activity independent of exposure to SARS-CoV-2.

SUBMITTER: Knopf J 

PROVIDER: S-EPMC9455008 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

altmetric image

Publications

NET Formation in Systemic Lupus Erythematosus: Changes during the COVID-19 Pandemic.

Knopf Jasmin J   Sjöwall Johanna J   Frodlund Martina M   Hinkula Jorma J   Herrmann Martin M   Sjöwall Christopher C  

Cells 20220823 17


The severity of the coronavirus disease in 2019 (COVID-19) is strongly linked to a dysregulated immune response. This fuels the fear of severe disease in patients with autoimmune disorders continuously using immunosuppressive/immunomodulating medications. One complication of COVID-19 is thromboembolism caused by intravascular aggregates of neutrophil extracellular traps (NETs) occluding the affected vessels. Like COVID-19, systemic lupus erythematosus (SLE) is characterized by, amongst others, a  ...[more]

Similar Datasets

| S-EPMC8792910 | biostudies-literature
| S-EPMC10504107 | biostudies-literature
| S-EPMC9896878 | biostudies-literature
| S-EPMC9896878 | biostudies-literature
| S-EPMC11551598 | biostudies-literature
| S-EPMC7250558 | biostudies-literature
| S-EPMC8405598 | biostudies-literature
| S-EPMC10232808 | biostudies-literature
| S-EPMC8914298 | biostudies-literature
| S-EPMC7661632 | biostudies-literature