P53 Controls Meiotic Prophase Progression and Crossover Formation.
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ABSTRACT:
SUBMITTER: Marcet-Ortega M
PROVIDER: S-EPMC9456223 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Publications
p53 Controls Meiotic Prophase Progression and Crossover Formation.
Marcet-Ortega Marina M Maldonado-Linares Andros A López-Panadés Maria M Roig Ignasi I
International journal of molecular sciences 20220829 17
Meiosis initiates with the formation of double strand breaks (DSBs) throughout the genome. To avoid genomic instability, these DSBs need to be correctly repaired by homologous recombination. Surveillance mechanisms involving the DNA damage response (DDR) pathway ATM-CHK2-p53 can detect the persistence of unrepaired DBSs and activate the recombination-dependent arrest at the pachytene stage. However, a complete understanding of p53 functions under normal physiological conditions remains lacking. ...[more]
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