Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy.

ABSTRACT: Psychiatric disorders such as schizophrenia are commonly associated with structural brain alterations affecting the cortex. Recent genetic evidence suggests circulating metabolites and other biochemical traits play a causal role in many psychiatric disorders which could be mediated by changes in the cerebral cortex. Here, we leveraged publicly available genome-wide association study data to explore shared genetic architecture and evidence for causal relationships between a panel of 50 biochemical traits and measures of cortical thickness and surface area. Linkage disequilibrium score regression identified 191 genetically correlated biochemical-cortical trait pairings, with consistent representation of blood cell counts and other biomarkers such as C-reactive protein (CRP), haemoglobin and

SUBMITTER: Kiltschewskij DJ 

PROVIDER: S-EPMC9458732 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature