LAMTOR3 is a prognostic biomarker in kidney renal clear cell carcinoma.

ABSTRACT:

Objective

The objective of the study was to investigate the expression of LAMTOR3 in kidney renal clear cell carcinoma (KIRC) and its clinical significance.

Methods

The expression of LAMTOR3 in KIRC and its relationship with clinical features were analyzed using the UALCAN online database. The results were verified using KIRC gene chip data and clinical specimens. The prognosis of KIRC patients was analyzed with the GEPIA2 database. GO, KEGG, and GSEA analyses were conducted to analyze the possible molecular mechanism of LAMTOR3 in KIRC. Immunohistochemical (IHC) and hematoxylin and eosin (H&E) staining were used for histopathological detection.

Results

UALCAN database analysis showed that LAMTOR3 expression in KIRC was significantly lower than in normal kidney tissue

SUBMITTER: Gong Y 

PROVIDER: S-EPMC9459259 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature