Development of multivariable risk signature based on four immune-related RNA-binding proteins to predict survival and immune status in lung adenocarcinoma.

ABSTRACT:

Background

This study aimed to construct a risk signature with predictive power based on immune-related RNA-binding proteins (RBPs) for lung adenocarcinoma (LUAD) patients.

Methods

The Cancer Genome Atlas (TCGA) database was used as the data source. Immune genes (IGs) were obtained from the Immunology Database and Analysis Portal (immPort) database. Differentially expressed RBPs and IGs between tumor and normal tissues were screened. For external validation, an independent cohort from the Gene-Expression Omnibus (GEO) database was used. The accuracy of the risk signature prediction was evaluated using Cox regression analysis and the receiver operating characteristic (ROC) curve.

Results

The risk signature was constructed from four immune-related and prognostic RBPs (<

SUBMITTER: You Q 

PROVIDER: S-EPMC9459526 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature