Exploring biomarkers of processing speed and executive function: The role of the anterior thalamic radiations.

ABSTRACT:

Introduction

Processing speed and executive function are often impaired after stroke and in typical aging. However, there are no reliable neurological markers of these cognitive impairments. The trail making test (TMT) is a common index of processing speed and executive function. Here, we tested candidate MRI markers of TMT performance in a cohort of older adults and individuals with chronic stroke.

Methods

In 61 older adults and 32 individuals with chronic stroke, we indexed white matter structure with region-specific lesion load (of white matter hyperintensities (WMHs) and stroke lesions) and diffusion tensor imaging (DTI) from four regions related to TMT performance: the anterior thalamic radiations (ATR), superior longitudinal fasciculus (SLF), forceps minor, and choline

SUBMITTER: Ferris J 

PROVIDER: S-EPMC9460835 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature