Proteotype coevolution and quantitative diversity across 11 mammalian species.

ABSTRACT: Evolutionary profiling has been largely limited to the nucleotide level. Using consistent proteomic methods, we quantified proteomic and phosphoproteomic layers in fibroblasts from 11 common mammalian species, with transcriptomes as reference. Covariation analysis indicates that transcript and protein expression levels and variabilities across mammals remarkably follow functional role, with extracellular matrix-associated expression being the most variable, demonstrating strong transcriptome-proteome coevolution. The biological variability of gene expression is universal at both interindividual and interspecies scales but to a different extent. RNA metabolic processes particularly show higher interspecies versus interindividual variation. Our results further indicate that while the ubiquit

SUBMITTER: Ba Q 

PROVIDER: S-EPMC9462687 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature