Dataset Information

Association of remnant cholesterol and lipid parameters with new-onset carotid plaque in Chinese population.

ABSTRACT:

Background

Remnant lipoprotein cholesterol (RC) is an independent risk factor for cardiovascular disease (CVD). However, the relationships of remnant cholesterol and other conventional lipid parameters with new-onset carotid plaque are not fully understood in the Chinese community-based population.

Materials and methods

A total of 872 plaque-free participants (51.39 ± 4.96 years old) with no history of CVD were included in this study. The plasma concentrations of RC were calculated by subtracting low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) from total cholesterol (TC). Multivariate regression models were used to evaluate and compare the associations between RC and other lipid parameters and new-onset carotid plaque.

Results

After a mean 6.77-year follow-up, the incidence of new-onset carotid plaque was 188 (21.56%). RC was significantly associated with new-onset carotid plaque [Odd ratio (OR) = 1.57 per 1 mmol/L increase, 95% confidence interval (CI): 1.03-2.41, p = 0.038]. The highest tertile of RC (T3 group) had the highest risk of new-onset carotid plaque (OR = 2.53, 95% CI: 1.63-3.95). Similar results were seen for increased other lipid parameters, but decreased HDL-C levels. When adding another lipid parameter into the adjusted model with RC simultaneously, only RC remained significantly associated with new-onset carotid plaque after adjusting for other lipid parameters (all p value < 0.005). Furthermore, RC was strongly associated with new-onset carotid plaque in participants with lower baseline LDL-C levels.

Conclusion

Increased RC levels were superior to other conventional lipid parameters to be associated with new-onset carotid plaque in the Chinese community-based population. Furthermore, RC should be considered in participants with lower LDL-C levels for the purpose of early atherosclerosis prevention.

SUBMITTER: Liu B

PROVIDER: S-EPMC9468421 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Association of remnant cholesterol and lipid parameters with new-onset carotid plaque in Chinese population.

Liu Bo B Fan Fangfang F Zheng Bo B Yang Ying Y Jia Jia J Sun Pengfei P Jiang Yimeng Y Li Kaiyin K Liu Jiahui J Chen Chuyun C Li Jianping J Zhang Yan Y Huo Yong Y

Frontiers in cardiovascular medicine 20220830

<h4>Background</h4>Remnant lipoprotein cholesterol (RC) is an independent risk factor for cardiovascular disease (CVD). However, the relationships of remnant cholesterol and other conventional lipid parameters with new-onset carotid plaque are not fully understood in the Chinese community-based population.<h4>Materials and methods</h4>A total of 872 plaque-free participants (51.39 ± 4.96 years old) with no history of CVD were included in this study. The plasma concentrations of RC were calculate ...[more]

PMID: 36110413

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Dataset Information

Association of remnant cholesterol and lipid parameters with new-onset carotid plaque in Chinese population.

Background

Materials and methods

Results

Conclusion

Publications

Association of remnant cholesterol and lipid parameters with new-onset carotid plaque in Chinese population.

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