Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults.

ABSTRACT: Seasonal influenza causes mild to severe respiratory infections and significant morbidity, especially in older adults. Transcriptomic analysis in populations across multiple flu seasons has provided insights into the molecular determinants of vaccine response. Still, the metabolic changes that underlie the immune response to influenza vaccination remain poorly characterized. We performed untargeted metabolomics to analyze plasma metabolites in a cohort of younger and older subjects before and after influenza vaccination to identify vaccine-induced molecular signatures. Metabolomic and transcriptomic data were combined to define networks of gene and metabolic signatures indicative of high and low antibody response in these individuals. We observed age-related differences in metabolic baseli

SUBMITTER: Chou CH 

PROVIDER: S-EPMC9470889 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature