Reduced bone morphogenic protein signaling along the gut-neuron axis by heat shock factor promotes longevity.

ABSTRACT: Aging is a complex and highly regulated process of interwoven signaling mechanisms. As an ancient transcriptional regulator of thermal adaptation and protein homeostasis, the Heat Shock Factor, HSF-1, has evolved functions within the nervous system to control age progression; however, the molecular details and signaling dynamics by which HSF-1 modulates age across tissues remain unclear. Herein, we report a nonautonomous mode of age regulation by HSF-1 in the Caenorhabditis elegans nervous system that works through the bone morphogenic protein, BMP, signaling pathway to modulate membrane trafficking in peripheral tissues. In particular, HSF-1 represses the expression of the neuron-specific BMP ligand, DBL-1, and initiates a complementary negative feedback loop within the intestine. By redu

SUBMITTER: Arneaud SLB 

PROVIDER: S-EPMC9470895 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature