Adipose mTORC2 is essential for sensory innervation in white adipose tissue and whole-body energy homeostasis.

ABSTRACT:

Objective

Adipose tissue, via sympathetic and possibly sensory neurons, communicates with the central nervous system (CNS) to mediate energy homeostasis. In contrast to the sympathetic nervous system, the morphology, role and regulation of the sensory nervous system in adipose tissue are poorly characterized.

Methods and results

Taking advantage of recent progress in whole-mount three-dimensional imaging, we identified a network of calcitonin gene-related protein (CGRP)-positive sensory neurons in murine white adipose tissue (WAT). We found that adipose mammalian target of rapamycin complex 2 (mTORC2), a major component of the insulin signaling pathway, is required for arborization of sensory neurons, but not of sympathetic neurons. Time course experiments revealed that adip

SUBMITTER: Frei IC 

PROVIDER: S-EPMC9472075 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature