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A new fluorescent boronic acid sensor based on carbazole for glucose sensing via aggregation-induced emission† † Electronic supplementary information (ESI) available. See https://doi.org/10.1039/d2ra04110c

ABSTRACT: A water-soluble fluorescent sensor based on carbazole pyridinium boronic acid (CPBA) was designed and synthesized. Its structure has been confirmed by CHN and 1H and 13C NMR, FT-IR, and MS spectral data. Fluorescence studies of the synthesized chemosensor CPBA showed a selective ratiometric fluorescent response for glucose among different monosaccharides. The results specified that CPBA is a pH-sensitive sensor that behaves differently in the absence and presence of glucose in the pH range 4–10. The pH, DLS, Job's plot, UV-visible, and fluorescence titration studies showed that the selectivity of CPBA towards glucose is through the aggregation-induced emission (AIE) phenomenon. The fluorescence emission intensity of CPBA changes by more than 2100 fold by adding glucose, whereas it is 2 fold for fructose. The calculated binding constant value of CPBA for glucose (K = 2.3 × 106 M−1) is 85 times greater than for fructose, indicating the high affinity of the sensor for glucose. An amphiphilic chemosensor for a highly selective ratiometric fluorescent response toward glucose via AIE is introduced. High binding constant (K = 2.3 × 106 M−1) and low detection limit (5.9 × 10−7 M) make it an efficient chemosensor for glucose.

SUBMITTER: Oloub M

PROVIDER: S-EPMC9473643 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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