Dataset Information

Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use.

ABSTRACT: This study aimed to elucidate whether low-density lipoprotein cholesterol (LDL-C) levels differentially affect functional outcomes after intravenous thrombolysis (IVT) depending on prestroke statin use. Patients with acute ischemic stroke treated with IVT were categorized into low, intermediate, and high LDL-C groups based on LDL-C levels at admission (< 100/100-130/ > 130 mg/dl, respectively). Multivariable logistic regression analyses were performed to explore the relationships between LDL-C and clinical outcomes (good outcomes at 3 months, modified Rankin Scale scores 0-2). The interaction between LDL-C levels and prestroke statin use regarding functional outcomes was investigated. Among the 4711 patients (age, 67 ± 12 years; males, 62.1%) who met the eligibility criteria, compared with the high LDL-C group, the low and intermediate LDL-C groups were not associated with good outcomes at 3 months according to the multivariable analysis. A potential interaction between the LDL-C group and prestroke statin use on good outcomes at 3 months was observed (P_interaction = 0.07). Among patients with prestroke statin use, low (aOR 1.84 [1.04-3.26]) and intermediate (aOR 2.31 [1.20-4.47]) LDL-C groups were independently associated with a greater likelihood of having a 3-month good outcome. Our study showed that LDL-C was not associated with a 3-month good outcome, but prestroke statin use could modify the influence of LDL-C levels on functional outcomes after IVT.

SUBMITTER: Kang YR

PROVIDER: S-EPMC9474509 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use.

Kang You-Ri YR Kim Joon-Tae JT Lee Ji Sung JS Kim Beom Joon BJ Kang Kyusik K Lee Soo Joo SJ Kim Jae Guk JG Cha Jae-Kwan JK Kim Dae-Hyun DH Park Tai Hwan TH Lee Kyung Bok KB Lee Jun J Hong Keun-Sik KS Cho Yong-Jin YJ Park Hong-Kyun HK Lee Byung-Chul BC Yu Kyung-Ho KH Oh Mi Sun MS Kim Dong-Eog DE Ryu Wi-Sun WS Choi Jay Chol JC Kwon Jee-Hyun JH Kim Wook-Joo WJ Shin Dong-Ick DI Sohn Sung Il SI Hong Jeong-Ho JH Park Man-Seok MS Choi Kang-Ho KH Cho Ki-Hyun KH Park Jong-Moo JM Lee Sang-Hwa SH Lee Juneyoung J Bae Hee-Joon HJ

Scientific reports 20220914 1

This study aimed to elucidate whether low-density lipoprotein cholesterol (LDL-C) levels differentially affect functional outcomes after intravenous thrombolysis (IVT) depending on prestroke statin use. Patients with acute ischemic stroke treated with IVT were categorized into low, intermediate, and high LDL-C groups based on LDL-C levels at admission (< 100/100-130/ > 130 mg/dl, respectively). Multivariable logistic regression analyses were performed to explore the relationships between LDL-C a ...[more]

PMID: 36104394

Similar Datasets

Project description:Background: The data on the relationship between statin use and clinical outcomes after intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) are in controversy. Objective: This systematic review and meta-analysis aimed to evaluate the safety and efficacy of statins administered prior to onset and during hospitalization in patients with AIS treated with IVT. Methods: We searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from inception until June 8, 2021. Comparative studies investigating statin effect on intracranial hemorrhage (ICH), functional outcomes, and mortality in adults with AIS treated with IVT were screened. Random-effect meta-analyses of odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were performed. The protocol was registered in PROSPERO (CRD42021254919). Results: Twenty-two observational studies were included, which involved 17,554 patients. The pooled estimates showed that pre-stroke statin use was associated with a higher likelihood of symptomatic ICH (OR 1.31; 95% CI 1.07-1.59; p = 0.008) and any ICH (OR 1.21; 95% CI 1.03-1.43; p = 0.02). However, the pre-stroke statin use was not significantly associated with the 3-month mortality, 3-month favorable functional outcome (FFO, modified Rankin Scale [mRS] score 0-1), and 3-month functional independence (FI; mRS score 0-2). However, in-hospital statin use was associated with a reduced risk of symptomatic ICH (OR 0.46; 95% CI 0.21-1.00; p = 0.045), any ICH (OR 0.51; 95% CI 0.27-0.98; p = 0.04), and 3-month mortality (OR 0.42; 95% CI 0.29-0.62; p < 0.001) and an increased probability of 3-month FFO (OR 1.33; 95% CI 1.02-1.744; p = 0.04) and 3-month FI (OR 1.41; 95% C, 1.11-1.80; p = 0.005). Conclusions: The present systematic review and meta-analysis suggests that in-hospital statin use after IVT may be safe and may have a favorable impact on clinical outcomes, a finding not observed in studies restricted to patients with pre-stroke statin use.

Dataset Information

Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use.

Publications

Differential influences of LDL cholesterol on functional outcomes after intravenous thrombolysis according to prestroke statin use.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets