Immunological Insights into Opioid-Free Anaesthesia in Oncological Surgery: A Scoping Review.

ABSTRACT:

Purpose of review

The influence of opioids on outcomes after cancer surgery when used, or avoided, intraoperatively remains unclear. There is a need to conduct a scoping review to explore the wider context and provide direction for future research. The review will examine the current state of evidence in humans, with a focus on immunological biomarkers and clinically relevant cancer outcomes in trials comparing opioid-free to opioid-based general anaesthesia.

Recent findings

There is limited research on this subject area, which is mainly focused on breast cancer. The most frequently evaluated immunological parameter is the neutrophil-to-lymphocyte ratio. Cancer outcomes are mainly focused on recurrence. The central knowledge gap is understanding how the cellular effects of o

SUBMITTER: Smith L 

PROVIDER: S-EPMC9474513 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature