Interaction between endometrial microbiota and host gene regulation in recurrent implantation failure.

ABSTRACT:

Aim

To learn about the interaction between endometrial microbiota and host gene regulation in recurrent implantation failure.

Methods

The endometrial microbiota of 111 patients (RIF, 75; CON, 36) was analyzed by using 16 s rRNA sequencing technology. Transcriptome sequencing analysis of the endometrial of 60 patients was performed by using high-throughput sequencing.

Results

We found that the structure and composition of endometrium microbiota community of RIF patients were significantly different from those in control group. The abnormality of microbial structure and composition might interfere with the implantation of embryos by affecting the immune adaptation of the endometrium and the formation of endometrial blood vessels.

Conclusions

Our research describe

SUBMITTER: Chen P 

PROVIDER: S-EPMC9474991 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature