Role of lymphoid lineage cells aberrantly expressing alarmins S100A8/A9 in determining the severity of COVID-19.

ABSTRACT:

Background

Alarmins S100A8 and S100A9 are recognized as hallmarks of severe COVID-19 and are primarily produced in myeloid cells, such as monocytes and neutrophils. As single-cell RNA-sequencing (scRNA-seq) data from patients with COVID-19 revealed the expression of S100A8/A9 in lymphoid cells in patients with severe COVID-19.

Objective

We investigated the characteristics of lymphoid cells expressing S100A8/A9 in COVID-19 patients.

Methods

Publicly available scRNA-seq data from patients with mild (N = 12) or severe (N = 7) COVID-19 were reanalyzed. The data were further divided into the following two groups based on the time of sample collection (from infection-onset): within 6 days (early phase) and after 6 days (late phase). Differential expression and gene set enri

SUBMITTER: Lee J 

PROVIDER: S-EPMC9476394 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature