Prevalence of thrombophilia-associated genetic risk factors in blood donors of a regional hospital in southern Brazil.

ABSTRACT:

Introduction

Thromboembolic events occur due to an imbalance in the hemostasis and some factors associated with this condition can be inherited. In order to evaluate the frequency of genotypes considered to be common hereditary risk factors for thrombophilia associated with venous thrombosis (g.1691G > A and g.20210G > A) and hyperhomocysteinemia (g.677C > T and g.1298A > C), samples from voluntary healthy blood donors at the Hospital de Clínicas de Porto Alegre were tested.

Methods

We examined 325 blood samples from blood donors collected from October 2017 to July 2018. Blood was collected on filter paper and the DNA was extracted for single nucleotide polymorphisms (SNPs) analysis using the qualitative real time polymerase chain reaction.

Results

The calculated freq

SUBMITTER: Dick-Guareschi J 

PROVIDER: S-EPMC9477773 | biostudies-literature | 2022 Jul-Sep

REPOSITORIES: biostudies-literature