Dendritic cell-derived IL-27 p28 regulates T cell program in pathogenicity and alleviates acute graft-versus-host disease.

ABSTRACT: Interleukin 27 (IL-27), a heterodimeric cytokine composed of Epstein-Barr virus-induced 3 and p28, is a pleiotropic cytokine with both pro-and anti-inflammatory properties. However, the precise role of IL-27 in acute graft-versus-host disease is not yet fully understood. In this study, utilizing mice with IL-27 p28 deficiency in dendritic cells (DCs), we demonstrated that IL-27 p28 deficiency resulted in impaired Treg cell function and enhanced effector T cell responses, corresponding to aggravated aGVHD in mice. In addition, using single-cell RNA sequencing, we found that loss of IL-27 p28 impaired Treg cell generation and promoted IL-1R2⁺TIGIT⁺ pathogenic CD4⁺ T cells in the thymus at a steady state. Mechanistically, IL-27 p28 deficiency promoted STAT1 ph

SUBMITTER: Gong H 

PROVIDER: S-EPMC9477797 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature