Daytime napping and Alzheimer's dementia: A potential bidirectional relationship.
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ABSTRACT: Introduction
Daytime napping is frequently seen in older adults. The longitudinal relationship between daytime napping and cognitive aging is unknown.Methods
Using data from 1401 participants of the Rush Memory and Aging Project, we examined the longitudinal change of daytime napping inferred objectively by actigraphy, and the association with incident Alzheimer's dementia during up to 14-year follow-up.Results
Older adults tended to nap longer and more frequently with aging, while the progression of Alzheimer's dementia accelerates this change by more than doubling the annual increases in nap duration/frequency. Longer and more frequent daytime naps were associated with higher risk of Alzheimer's dementia. Interestingly, more excessive (longer or more frequent) daytime napping was correlated with worse cognition a year later, and conversely, worse cognition was correlated with more excessive naps a year later.Discussion
Excessive daytime napping and Alzheimer's dementia may possess a bidirectional relationship or share common pathophysiological mechanisms.
SUBMITTER: Li P
PROVIDER: S-EPMC9481741 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
Daytime napping and Alzheimer's dementia: A potential bidirectional relationship.
Li Peng P Gao Lei L Yu Lei L Zheng Xi X Ulsa Ma Cherrysse MC Yang Hui-Wen HW Gaba Arlen A Yaffe Kristine K Bennett David A DA Buchman Aron S AS Hu Kun K Leng Yue Y
Alzheimer's & dementia : the journal of the Alzheimer's Association 20220317 1
<h4>Introduction</h4>Daytime napping is frequently seen in older adults. The longitudinal relationship between daytime napping and cognitive aging is unknown.<h4>Methods</h4>Using data from 1401 participants of the Rush Memory and Aging Project, we examined the longitudinal change of daytime napping inferred objectively by actigraphy, and the association with incident Alzheimer's dementia during up to 14-year follow-up.<h4>Results</h4>Older adults tended to nap longer and more frequently with ag ...[more]
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Project description:IntroductionThere is inconsistent evidence on the associations of sleep duration and daytime napping with dementia risk.MethodsIn the Million Women Study, a total of 830,716 women (mean age, 60 years) were asked about sleep duration (<7, 7-8, >8 hours) and daytime napping (rarely/never, sometimes, usually) in median year 2001, and were followed for the first hospital record with any mention of dementia. Cox regression estimated dementia detection risk ratios (RRs) during 17-year follow-up in 5-year intervals.ResultsWith 34,576 dementia cases, there was strong attenuation over follow-up in the RRs related to long sleep duration (>8 vs 7-8 hours) and usually napping (vs rarely/never). Short sleep duration was modestly, positively associated with dementia in the long term (RR = 1.08, 95% confidence interval [CI] 1.04-1.12).DiscussionThere was little evidence to suggest that long sleep duration and regular napping are associated with long-term dementia risk. Short sleep duration was modestly associated with dementia risk, but residual confounding cannot be excluded.HighlightsLong sleep duration was not associated with long-term dementia risk. Daytime napping was not associated with long-term dementia risk. There is some evidence for a small higher risk of dementia related to short sleep.
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