Association of daytime napping frequency and schizophrenia: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

The bidirectional causal association between daytime napping frequency and schizophrenia is unclear.

Methods

A bidirectional two-sample Mendelian randomization (MR) analysis was conducted with summary statistics of top genetic variants associated with daytime napping frequency and schizophrenia from genome-wide association studies (GWAS). The single nucleotide polymorphisms (SNPs) data of daytime napping frequency GWAS came from the UK Biobank (n = 452,633) and 23andMe study cohort (n = 541,333), while the schizophrenia GWAS came from the Psychiatric Genomics Consortium (PGC, 36,989 cases and 113,075 controls). The inverse variance weighted (IVW) analysis was the primary method, with the weighted median, MR-Robust Adjusted Profile Score (RAPS), Radial MR and MR-Pl

SUBMITTER: Ma J 

PROVIDER: S-EPMC9746219 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature