The power and the promise of CRISPR/Cas9 genome editing for clinical application with gene therapy.

ABSTRACT:

Background

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is derived from the bacterial innate immune system and engineered as a robust gene-editing tool. Due to the higher specificity and efficiency of CRISPR/Cas9, it has been widely applied to many genetic and non-genetic disease, including cancers, genetic hemolytic diseases, acquired immunodeficiency syndrome, cardiovascular diseases, ocular diseases, and neurodegenerative diseases, and some X-linked diseases. Furthermore, in terms of the therapeutic strategy of cancers, many researchers used the CRISPR/Cas9 technique to cure or alleviate cancers through different approaches, such as gene therapy and immune therapy.

Aim of review

Here, we conclude the recent application and clinical trials of CRISPR/C

SUBMITTER: Guo N 

PROVIDER: S-EPMC9481961 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature