Higher serum sPD-L1 levels after radiotherapy indicate poor outcome in hepatocellular carcinoma patients.

ABSTRACT:

Background

Our preclinical research reveals that radiotherapy (RT) promoted PD-L1 upregulation in tumor tissues and that higher PD-L1 after RT worsened the prognosis through immunosuppression. We sought to validate our experimental results in clinical cohorts and promote clinical application.

Patients and methods

In cohort 1, formalin-fixed paraffin-embedded samples were obtained from 46 HCC patients, 23 of whom received preoperative RT and the other 23 received direct surgery. A prospectively collected database contained 122 HCC patients treated with liver RT were enrolled in cohort 2. Blood samples were taken a day before and two weeks after RT. Patients in cohort 2 were further divided into two groups, exploration (73 patients) and validation (49 patients) groups.

Resu

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9483785 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature