Dataset Information

First in-human quantitative plaque characterization with ultra-high resolution coronary photon-counting CT angiography.

ABSTRACT:

Purpose

To assess the effect of ultra-high-resolution coronary CT angiography (CCTA) with photon-counting detector (PCD) CT on quantitative coronary plaque characterization.

Materials and methods

In this IRB-approved study, 22 plaques of 20 patients (7 women; mean age 77 ± 8 years, mean body mass index 26.1 ± 3.6 kg/m²) undergoing electrocardiography (ECG)-gated ultra-high-resolution CCTA with PCD-CT were included. Images were reconstructed with a smooth (Bv40) and a sharp (Bv64) vascular kernel, with quantum iterative reconstruction (strength level 4), and using a slice thickness of 0.6, 0.4, and 0.2 mm, respectively (field-of-view 200 mm × 200 mm, matrix size 512 × 512 pixels). Reconstructions with the Bv40 kernel and slice thickness of 0.6 mm served as the reference standard. After identification of a plaque in coronary arteries with a vessel diameter ≥2 mm, plaque composition was determined using a dedicated, semi-automated plaque quantification software. Total plaque, calcified, fibrotic, and lipid-rich plaque components were quantified in all datasets.

Results

Median plaque volume was highest (23.5 mm³, interquartiles 17.9-34.3 mm³) for reconstructions with the reference standard and lowest for ultra-high-resolution reconstructions with a slice thickness of 0.2 mm and the Bv64 kernel (18.1 mm³, interquartiles 14.1-25.8 mm³, p < 0.001). Reconstructions with the reference standard showed largest calcified (85.1%, interquartiles 76.4-91.1%) and smallest lipid-rich plaque components (0.5%, interquartiles 0.0-1.5%). Smallest calcified plaque components (75.2%, interquartiles 69.9-80.8%) and largest lipid-rich components (6.7%, interquartiles 5.1-8.4%) were found for ultra-high-resolution reconstructions with a slice thickness of 0.2 mm and the Bv64 kernel. At an identical slice thickness, volume of calcified components was always lower, and volume of lipid-rich components was always higher for reconstructions with the Bv64 kernel compared with reconstructions with the Bv40 kernel (all, p < 0.001).

Conclusion

This patient study indicates significant differences of ultra-high-resolution scanning with PCD-CT on quantitative coronary plaque characterization. Reduced blooming artifacts may allow improved visualization of fibrotic and lipid-rich plaque components with the ultra-high-resolution mode of PCD-CT.

SUBMITTER: Mergen V

PROVIDER: S-EPMC9485480 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

First in-human quantitative plaque characterization with ultra-high resolution coronary photon-counting CT angiography.

Mergen Victor V Eberhard Matthias M Manka Robert R Euler André A Alkadhi Hatem H

Frontiers in cardiovascular medicine 20220906

<h4>Purpose</h4>To assess the effect of ultra-high-resolution coronary CT angiography (CCTA) with photon-counting detector (PCD) CT on quantitative coronary plaque characterization.<h4>Materials and methods</h4>In this IRB-approved study, 22 plaques of 20 patients (7 women; mean age 77 ± 8 years, mean body mass index 26.1 ± 3.6 kg/m<sup>2</sup>) undergoing electrocardiography (ECG)-gated ultra-high-resolution CCTA with PCD-CT were included. Images were reconstructed with a smooth (Bv40) and a sh ...[more]

PMID: 36148053

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Dataset Information

First in-human quantitative plaque characterization with ultra-high resolution coronary photon-counting CT angiography.

Purpose

Materials and methods

Results

Conclusion

Publications

First in-human quantitative plaque characterization with ultra-high resolution coronary photon-counting CT angiography.

Similar Datasets

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