Myoferlin disturbs redox equilibrium to accelerate gastric cancer migration.

ABSTRACT:

Objective

In contrast to normal cells, in which reactive oxygen species (ROS) are maintained in redox equilibrium, cancer cells are characterized by ectopic ROS accumulation. Myoferlin, a newly identified oncogene, has been associated with tumor metastasis, intracellular ROS production, and energy metabolism. The mechanism by which myoferlin regulates gastric cancer cell migration and ROS accumulation has not been determined.

Methods

Myoferlin expression, intracellular ROS levels, the ratios of reduced to oxidized glutathione (GSH/GSSG) and nicotinamide adenine dinucleotide phosphate (NADPH/NADP+) and migratory ability were measured in gastric cancer cells in vitro and in the TCGA and GEO databases in silico.

Results

Myoferlin was found to be more highly

SUBMITTER: Shi H 

PROVIDER: S-EPMC9486956 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature