Alterations in bile acids as metabolic signatures in the patients with human adenovirus type 7 infection.

ABSTRACT:

Objectives

The changes in metabolism by human adenovirus (HAdV) infection was unclear. The potential mechanism of HAdV-7 causing acute respiratory tract infection was explored.

Methods

Totally 35 patients with HAdV-7 infection, 32 asymptomatic cases with HAdV-7 and 14 healthy controls were enrolled from an outbreak of HAdV-7 in the army. The serum samples were analyzed by untargeted and targeted metabolomics. The effects of differential metabolites were verified on HAdV-7 replication in an A549 cell line.

Results

The untargeted metabolomics analysis revealed more significant changes in the classes of sphingolipids, polyketides, glycerolipids, fatty acyls, and carboxylic acids and their derivatives in the patients with HAdV-7 than in healthy controls. Two key metabolic

SUBMITTER: Xu W 

PROVIDER: S-EPMC9489940 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature