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Catalytic Hydrodifluoroalkylation of Unactivated Olefins.

ABSTRACT: Herein, we report a modular catalytic technique that streamlines the preparation of gem-difluoroalkanes from unactivated sp³ precursors. The method is characterized by its simplicity, generality, and site selectivity, including the functionalization of advanced intermediates and olefin feedstocks. Our approach is enabled by a cooperative interplay of halogen- and hydrogen-atom transfer, thus offering a new entry point to difluorinated alkyl bioisosteres of interest in drug discovery.

SUBMITTER: Yue WJ

PROVIDER: S-EPMC9490814 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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Catalytic Hydrodifluoroalkylation of Unactivated Olefins.

Yue Wen-Jun WJ Day Craig S CS Brenes Rucinski Adrian J AJ Martin Ruben R

Organic letters 20220710 28

Herein, we report a modular catalytic technique that streamlines the preparation of gem-difluoroalkanes from unactivated sp3 precursors. The method is characterized by its simplicity, generality, and site selectivity, including the functionalization of advanced intermediates and olefin feedstocks. Our approach is enabled by a cooperative interplay of halogen- and hydrogen-atom transfer, thus offering a new entry point to difluorinated alkyl bioisosteres of interest in dr ...[more]

PMID: 35815401

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