A practical guide to chimerism analysis: Review of the literature and testing practices worldwide.

ABSTRACT:

Background and purpose

Currently there are no widely accepted guidelines for chimerism analysis testing in hematopoietic cell transplantation (HCT) patients. The objective of this review is to provide a practical guide to address key aspects of performing and utilizing chimerism testing results. In developing this guide, we conducted a survey of testing practices among laboratories that are accredited for performing engraftment monitoring/chimerism analysis by either the American Society for Histocompatibility & Immunogenetics (ASHI) and/or the European Federation of Immunogenetics (EFI). We interpreted the survey results in the light of pertinent literature as well as the experience in the laboratories of the authors.

Recent developments

In recent years there has been signi

SUBMITTER: Blouin AG 

PROVIDER: S-EPMC9492519 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature