Dataset Information
Data for: A practical guide for analysis of histone post-translational modifications by mass spectrometry: best practices and pitfalls
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (ncbitaxon:9606)
SUBMITTER: 
John Denu
PROVIDER: MSV000084298 | MassIVE |
REPOSITORIES: MassIVE
Publications
A practical guide for analysis of histone post-translational modifications by mass spectrometry: Best practices and pitfalls.
Methods (San Diego, Calif.) 20191207
Advances in mass spectrometry (MS) have revolutionized the ability to measure global changes in histone post-translational modifications (PTMs). The method routinely quantifies over 60 modification states in a single sample, far exceeding the capabilities of traditional western blotting. Thus, MS-based histone analysis has become an increasingly popular tool for understanding how genetic and environmental factors influence epigenetic states. However, histone proteomics experiments exhibit unique ...[more]
