Association of CD40 gene polymorphisms and immune thrombocytopenic purpura in the adult Egyptian population.

ABSTRACT:

Background

The pathophysiology underlying primary adult immune thrombocytopenic purpura (ITP) has not yet been identified. However, many mechanisms affect the immune system, causing defective tolerance to self-platelets and megakaryocytes. Cluster of differentiation 40 (CD40) contributes to both humoral and cell-mediated immune responses.

Methods

This case‒control study was conducted to detect rs4810485G>T and rs1883832C>T polymorphisms of CD40 in Egyptian patients with persistent/chronic ITP to clarify their possible association with chronic disease evolution. This study included 50 patients with persistent/chronic ITP and 50 healthy controls. Genotyping was performed using the polymerase chain reaction‒restriction fragment length polymorphism technique.

Results

Geno

SUBMITTER: Ellithy HN 

PROVIDER: S-EPMC9492531 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature