Balancing the Virulence and Antimicrobial Resistance in VISA DAP-R CA-MRSA Superbug.

ABSTRACT:

Background

Methicillin-resistant Staphylococcus aureus (MRSA) with intermediate resistance to Vancomycin (VISA) is reported worldwide. These strains frequently emerge among hospital-associated (HA)-MRSA and rarely within community-acquired (CA)-MRSA. Here, the genomic and transcriptomic adaptations distinguishing VISA daptomycin resistant (DAP-R) CA-MRSA, which emerged in a hospitalized patient under glycopeptide treatment, were explored.

Methods

Whole-genome sequencing, RNA-Seq and bioinformatics were carried out.

Results

Our CA-MRSA clustered in the USA400 lineage showing additional antimicrobial resistance (AMR) versus DAP and glycopeptides. Resistomics revealed adaptations related to glycopeptide, daptomycin and rifampin resistance (mprF nsSNPS and o

SUBMITTER: Salemi R 

PROVIDER: S-EPMC9495084 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature