Infiltration Profile of Regulatory T Cells in Osteoarthritis-Related Pain and Disability.

ABSTRACT: Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4⁺CD25^+/high CD127^low/-) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 pati

SUBMITTER: Nees TA 

PROVIDER: S-EPMC9495462 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature