Active forgetting requires Sickie function in a dedicated dopamine circuit in Drosophila.

ABSTRACT: Forgetting is an essential component of the brain's memory management system, providing a balance to memory formation processes by removing unused or unwanted memories, or by suppressing their expression. However, the molecular, cellular, and circuit mechanisms underlying forgetting are poorly understood. Here we show that the memory suppressor gene, sickie, functions in a single dopamine neuron (DAn) by supporting the process of active forgetting in Drosophila. RNAi knockdown (KD) of sickie impairs forgetting by reducing the Ca²⁺ influx and DA release from the DAn that promotes forgetting. Coimmunoprecipitation/mass spectrometry analyses identified cytoskeletal and presynaptic active zone (AZ) proteins as candidates that physically interact with Sickie, and

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9499536 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature