Functional microvascularization of human myocardium in vitro.
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ABSTRACT:
SUBMITTER: King O
PROVIDER: S-EPMC9499876 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Publications
Functional microvascularization of human myocardium <i>in vitro</i>.
King Oisín O Cruz-Moreira Daniela D Sayed Alaa A Kermani Fatemeh F Kit-Anan Worrapong W Sunyovszki Ilona I Wang Brian X BX Downing Barrett B Fourre Jerome J Hachim Daniel D Randi Anna M AM Stevens Molly M MM Rasponi Marco M Terracciano Cesare M CM
Cell reports methods 20220829 9
In this study, we report static and perfused models of human myocardial-microvascular interaction. In static culture, we observe distinct regulation of electrophysiology of human induced pluripotent stem cell derived-cardiomyocytes (hiPSC-CMs) in co-culture with human cardiac microvascular endothelial cells (hCMVECs) and human left ventricular fibroblasts (hLVFBs), including modification of beating rate, action potential, calcium handling, and pro-arrhythmic substrate. Within a heart-on-a-chip m ...[more]
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