The Risk of Cirrhosis and Its Complications Based on PNPLA3 rs738409 G Allele Frequency.

ABSTRACT:

Background

Data regarding the influence of patatin-like phospholipase domain-containing 3 (PNPLA3) polymorphism for patients with liver cirrhosis (LC) are scarce.

Objective

This study assesses the role of the PNPLA3 polymorphism for the development of LC and its complications by the findings of genetic examinations.

Methods

Patients with LC caused by virus (n = 157), alcohol (n = 104), nonalcoholic fatty liver disease (NAFLD) (n = 106), or autoimmune disease (n = 33) and without LC (n = 128) were enrolled. LC was composed of the presence and absence of complications, such as variceal bleeding, hepatic ascites, and hepatic encephalopathy. To assess the role of the PNPLA3 polymorphism, odds ratio (OR) for the rs738409 variant was calculated for the patients between (i)

SUBMITTER: Shao X 

PROVIDER: S-EPMC9501715 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature