Unknown

Dataset Information

0

Survival After Simultaneous Pancreas-Kidney Transplantation in Type 1 Diabetes: The Critical Role of Early Pancreas Allograft Function.


ABSTRACT: Simultaneous pancreas-kidney transplantation (SPK) carries about a 7%-22% risk of technical failure, but the impact of early pancreas allograft loss on subsequent kidney graft and patient survival is not well-defined. We examined national transplant registry data for type 1 diabetic patients who received SPK between 2000 and 2021. Associations of transplant type (i.e., SPK, deceased-donor kidney transplant [DDKA], living-donor kidney transplant [LDKA]) with kidney graft failure and patient survival were estimated by multivariable inverse probability of treatment-weighted accelerated failure-time models. Compared to SPK recipients with a functioning pancreas graft 3 months posttransplant (SPK,P+), LDKA had 18% (Time Ratio [TR] 0.82, 95%CI: 0.70-0.95) less graft survival time and 18% (TR 0.82, 95%CI: 0.68-0.97) less patient survival time, DDKA had 23% (TR 0.77, 95%CI: 0.68-0.87) less graft survival time and 29% (TR 0.71, 95%CI: 0.62-0.81) less patient survival time, and SPK with early pancreas graft loss had 34% (TR 0.66, 95%CI: 0.56-0.78) less graft survival time and 34% (TR 0.66, 95%CI: 0.55-0.79) less patient survival time. In conclusion, SPK,P+ recipients have better kidney allograft and patient survival compared with LDKA and DDKA. Early pancreas graft failure results in inferior kidney and patient survival time compared to kidney transplant alone.

SUBMITTER: Ji M 

PROVIDER: S-EPMC9510367 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

altmetric image

Publications

Survival After Simultaneous Pancreas-Kidney Transplantation in Type 1 Diabetes: The Critical Role of Early Pancreas Allograft Function.

Ji Mengmeng M   Wang Mei M   Hu Wenjun W   Ibrahim Mohamed M   Lentine Krista L. KL   Merzkani Massini M   Murad Haris H   Al-Hosni Yazen Y   Parsons Ronald R   Wellen Jason J   Chang Su-Hsin SH   Alhamad Tarek T  

Transplant international : official journal of the European Society for Organ Transplantation 20220912


Simultaneous pancreas-kidney transplantation (SPK) carries about a 7%-22% risk of technical failure, but the impact of early pancreas allograft loss on subsequent kidney graft and patient survival is not well-defined. We examined national transplant registry data for type 1 diabetic patients who received SPK between 2000 and 2021. Associations of transplant type (i.e., SPK, deceased-donor kidney transplant [DDKA], living-donor kidney transplant [LDKA]) with kidney graft failure and patient survi  ...[more]

Similar Datasets

| S-EPMC7573738 | biostudies-literature
| S-EPMC8362174 | biostudies-literature
| S-EPMC6647173 | biostudies-literature
| S-EPMC7971118 | biostudies-literature
| S-EPMC4286161 | biostudies-literature
| S-EPMC10090504 | biostudies-literature
| S-EPMC10086771 | biostudies-literature
| S-EPMC8070486 | biostudies-literature
| S-EPMC11573160 | biostudies-literature