Pharmacokinetic study comparing doxorubicin concentrations after chemoembolization or intravenous administration in dogs with naturally occurring nonresectable hepatic carcinoma.

ABSTRACT:

Background

Chemoembolization is a viable treatment option for patients with nonresectable hepatic carcinoma (HC) and may allow delivery of chemotherapeutic drugs with decreased systemic toxicity.

Hypothesis/objective

Compare the serum concentrations of doxorubicin after chemoembolization or IV administration in the same patient. We hypothesized that locoregional delivery may result in increased tumor chemotherapeutic drug concentrations, reflected by decreased measurable serum drug concentrations. Adverse hematological events were hypothesized to be decreased after locoregional delivery.

Animals

Seventeen client-owned dogs with incompletely resectable HC.

Methods

Prospective, single-arm clinical trial. Drug-eluting bead transarterial chemoembolization was perfo

SUBMITTER: Samuel N 

PROVIDER: S-EPMC9511073 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature