Longitudinal COVID-19 immune trajectories in patients with neurological autoimmunity on anti-CD20 therapy.

ABSTRACT:

Background and objectives

During the COVID-19 pandemic, B cell depleting therapies pose a clinical concern for patients with neuroimmune conditions, as patients may not mount a sufficient immune response to SARS-CoV-2 infection and vaccinations. Studies to-date have reported conflicting results on the degree of antibody production post-SARS-CoV-2 infection and vaccinations in B cell depleted patients, focusing primarily on short-term immune profiling. Our objective was to follow longitudinal immune responses in COVID-19 B cell depleted patients with neuroimmune disorders post-COVID-19 and SARS-CoV-2-vaccination.

Methods

CD20 B cell depleted autoimmune patients and age/sex-matched controls positive for SARS-CoV-2 were recruited at Dell Medical School, UT Austin between 2020 a

SUBMITTER: Bazzi SA 

PROVIDER: S-EPMC9511881 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature