Proteomics

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Longitudinal serum proteome analysis in COVID-19

ABSTRACT: COVID-19 is associated with endotheliopathy and coagulopathy, potentially leading to multi-organ failure. However, the direct mechanisms by which SARS-CoV-2 infection leads to endothelial damage are unclear. Here we developed an infection-competent human vascular organoid from pluripotent stem cells amenable for modeling endotheliopathy. Longitudinal proteome analysis of COVID-19 patient serume was conducted to gain further insights into molecular mediators that drive vascular complications. Differential signatures were identified by comparing late- and early- recovery groups. In the late recovery group, there were significant increases in FCGBP (anti-inflammation), SFTPB (lung surfactant metabolism), coagulation system (A2M and SERPINA1), and complement proteins (C7, CFHR5, and CFD) on day 1-2.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood

DISEASE(S): Severe Acute Respiratory Syndrome

SUBMITTER: Fuminori Sugihara  

LAB HEAD: Takanori Takebe

PROVIDER: PXD044386 | Pride | 2025-05-06

REPOSITORIES: Pride

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F073652.dat Other
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Publications

Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.

Kawakami Eri E   Saiki Norikazu N   Yoneyama Yosuke Y   Moriya Chiharu C   Maezawa Mari M   Kawamura Shuntaro S   Kinebuchi Akiko A   Kono Tamaki T   Funata Masaaki M   Sakoda Ayaka A   Kondo Shigeru S   Ebihara Takeshi T   Matsumoto Hisatake H   Togami Yuki Y   Ogura Hiroshi H   Sugihara Fuminori F   Okuzaki Daisuke D   Kojima Takashi T   Deguchi Sayaka S   Vallee Sebastien S   McQuade Susan S   Islam Rizwana R   Natarajan Madhusudan M   Ishigaki Hirohito H   Nakayama Misako M   Nguyen Cong Thanh CT   Kitagawa Yoshinori Y   Wu Yunheng Y   Mori Kensaku K   Hishiki Takayuki T   Takasaki Tomohiko T   Itoh Yasushi Y   Takayama Kazuo K   Nio Yasunori Y   Takebe Takanori T  

Cell stem cell 20231001 10

COVID-19 is linked to endotheliopathy and coagulopathy, which can result in multi-organ failure. The mechanisms causing endothelial damage due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain elusive. Here, we developed an infection-competent human vascular organoid from pluripotent stem cells for modeling endotheliopathy. Longitudinal serum proteome analysis identified aberrant complement signature in critically ill patients driven by the amplification cycle regulated by c  ...[more]

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