Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans.

ABSTRACT: Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough infections on memory responses. Here, we examine the memory antibodies that develop after a third or fourth antigenic exposure by Delta or Omicron BA.1 infection, respectively. A third exposure to antigen by Delta breakthrough increases the number of memory B cells that produce antibodies with comparable potency and breadth to a third mRNA vaccine dose. A fourth antigenic exposure with Omicron BA.1 infection increased variant-specific plasma antibody and memory B cell responses. However, the fourth exposure did not increase the overall frequency of memory B cells or their general potency or breadth compared to a third mRNA vaccine dose. In

SUBMITTER: Wang Z 

PROVIDER: S-EPMC9513381 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature