DNA Methylation in Gestational Diabetes and its Predictive Value for Postpartum Glucose Disturbances.

ABSTRACT:

Context

DNA methylation in the diagnosis of gestational diabetes.

Objective

To assess the value of DNA methylation in the diagnosis of gestational diabetes (GDM) and in the prediction of maternal postpartum glucose disturbances.

Methods

Two-stage observational study performed between July 2006 and December 2010, at University Hospital. Forty-eight randomly selected pregnant women formed the discovery cohort (24 with GDM and 24 controls) and 252 pregnant women (94 with GDM and 158 controls) formed the replication cohort. GDM women were re-evaluated 4 years postpartum. The main outcome measures were GDM, type 2 diabetes or prediabetes at 4 years postpartum.

Results

We identified 3 CpG sites related to LINC00917, TRAPPC9, and LEF1 that were differentially methylat

SUBMITTER: Ballesteros M 

PROVIDER: S-EPMC9516049 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature