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Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled, phase 2 trial.

ABSTRACT:

SUBMITTER: Zhang Y

PROVIDER: S-EPMC9517939 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Immunogenicity, durability, and safety of an mRNA and three platform-based COVID-19 vaccines as a third dose following two doses of CoronaVac in China: A randomised, double-blinded, placebo-controlled, phase 2 trial.

Zhang Yuemiao Y Ma Xupu X Yan Guanghong G Wu Ying Y Chen Yanli Y Zhou Zumi Z Wan Na N Su Wei W Liu Feng-Wei FW Dai Mu-Xian MX Yang Mei M Li Chunmei C Yu Xuanjing X Zhang Liang L Wang Zhongfang Z Zhou Tai-Cheng TC You Dingyun D Wei Jia J Zhang Zijie Z

EClinicalMedicine 20220928

<h4>Background</h4>More effective vaccine candidates against variants of concern as a booster dose are needed in people primed with two-dose inactivated COVID-19 vaccines.<h4>Methods</h4>This randomised, double-blinded, investigator-initiated phase 2 trial aims to evaluate immunogenicity, durability, and safety of an mRNA vaccine candidate (RQ3013) and three other platform vaccines (an adenovirus-vectored vaccine candidate [ChAdTS-S], a recombinant protein vaccine candidate [ZR202-CoV], and an i ...[more]

PMID: 36188435

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