Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.

ABSTRACT:

Background

One hallmark of sepsis is the reduced number of lymphocytes, termed lymphopenia, that occurs from decreased lymphocyte proliferation or increased cell death contributing to immune suppression. Histone modification enzymes regulate immunity by their epigenetic and non-epigenetic functions; however, the role of these enzymes in lymphopenia remains elusive.

Methods

We used molecular biological approaches to investigate the high expression and function of a chromatin modulator protein arginine N-methyltransferase 4 (PRMT4)/coactivator-associated arginine methyltransferase 1 in human samples from septic patients and cellular and animal septic models.

Results

We identified that PRMT4 is elevated systemically in septic patients and experimental sepsis. Gram-negati

SUBMITTER: Lai Y 

PROVIDER: S-EPMC9522923 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature