Immunological characteristics of severe acute hepatitis of unknown origin in a child post SARS-CoV-2 infection.

ABSTRACT: Recent studies have reported that pediatric acute liver failure of unknown origin is immune-mediated, with CD8⁺ T cells playing a key role. Moreover, investigation of superantigen-mediated T-cell activation by the SARS-CoV-2 spike protein in pediatric severe acute hepatitis is needed in the context of the proposed mechanism of multisystem inflammatory syndrome in children (MIS-C). We investigated the immunological characteristics of a Japanese pediatric patient with severe acute hepatitis post SARS-CoV-2 infection. The patient demonstrated autoimmune hepatitis-like liver histology with CD8⁺ lymphocyte-predominant infiltration. There was Th1-type immune skewing, including remarkable peripheral CD8⁺ T-cell activation and a skewed T cell receptor repertoire. W

SUBMITTER: Morita A 

PROVIDER: S-EPMC9527691 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature