ZBTB46 defines and regulates ILC3s that protect the intestine.

ABSTRACT: RORγt is a lineage-specifying transcription factor that is expressed by immune cells that are enriched in the gastrointestinal tract and promote immunity, inflammation and tissue homeostasis^1-15. However, fundamental questions remain with regard to the cellular heterogeneity among these cell types, the mechanisms that control protective versus inflammatory properties and their functional redundancy. Here we define all RORγt⁺ immune cells in the intestine at single-cell resolution and identify a subset of group 3 innate lymphoid cells (ILC3s) that expresses ZBTB46, a transcription factor specifying conventional dendritic cells^16-20. ZBTB46 is robustly expressed by CCR6⁺ lymphoid-tissue-inducer-like ILC3s that are developmentally and phenotypically

SUBMITTER: Zhou W 

PROVIDER: S-EPMC9528687 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature